Applications of Genome Editing Technology in Animal Disease Modeling and Gene Therapy

3Citations
Citations of this article
30Readers
Mendeley users who have this article in their library.

Abstract

Genome editing technology is a technique for targeted genetic modifications, enabling the knockout and addition of specific DNA fragments. This technology has been widely used in various types of biomedical research, clinics and agriculture. In terms of disease research, constructing appropriate animal models is necessary. Combining reproductive technology with genome editing, many animal disease models have been generated for basic and clinical research. In addition, precisely targeted modifications allow genome editing to flourish in the field of gene therapy. Many mutations refractory to traditional gene therapy could be permanently corrected at the DNA level. Thus, genome editing is undoubtedly a promising technology for gene therapy. In this review, we mainly introduce the applications of genome editing in constructing animal disease models and gene therapies, as well as its future prospects and challenges.

Cite

CITATION STYLE

APA

Li, Q., Qin, Z., Wang, Q., Xu, T., Yang, Y., & He, Z. (2019, January 1). Applications of Genome Editing Technology in Animal Disease Modeling and Gene Therapy. Computational and Structural Biotechnology Journal. Elsevier B.V. https://doi.org/10.1016/j.csbj.2019.05.006

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free