Trophoblast stem cells (TSCs) are derived from the early mouse embryo and can substantially contribute to placental development. Two studies by Kubaczka et al. (2015) and Benchetrit et al. (2015) in this issue of Cell Stem Cell now report reprogramming mouse fibroblasts into TSCs, surmounting the first lineage barrier established in development and providing new tools for researching placental specification and diseases.
Parenti, A., & Ralston, A. (2015, November 5). Three, two, one⋯ TROPHO-BLAST OFF! Cell Stem Cell. Cell Press. https://doi.org/10.1016/j.stem.2015.10.005