C-Sibelia: An easy-to-use and highly accurate tool for bacterial genome comparison

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Abstract

We present C-Sibelia, a highly accurate and easy-to-use software tool for comparing two closely related bacterial genomes, which can be presented as either finished sequences or fragmented assemblies. C-Sibelia takes as input two FASTA files and produces: (1) a VCF file containing all identified single nucleotide variations and indels; (2) an XMFA file containing alignment information. The software also produces Circos diagrams visualizing high level genomic architecture for rearrangement analyses. C-Sibelia is a part of the Sibelia comparative genomics suite, which is freely available under the GNU GPL v.2 license at http://sourceforge.net/projects/sibelia-bio. C-Sibelia is compatible with Unix-like operating systems. A web-based version of the software is available at http://etool.me/software/csibelia.

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Pham, S., Minkin, I., Pham, H., Starostina, E., & Vyahhi, N. (2013). C-Sibelia: An easy-to-use and highly accurate tool for bacterial genome comparison. F1000Research, 2. https://doi.org/10.12688/f1000research.2-258.v1

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