Mice lacking leptin receptors are grossly obese and diabetic, in part due to dysfunction in brain circuits important for energy homeostasis. Transplantation of leptin receptor-expressing hypothalamic progenitor neurons into the brains of leptin receptor deficient mice led to integration into neural circuits, reduced obesity, and normalized circulating glucose levels. © 2012 Elsevier Inc.
Sternson, S. M. (2012, February 8). Neuron transplantation partially reverses an obesity disorder in mice. Cell Metabolism. Cell Press. https://doi.org/10.1016/j.cmet.2012.01.011