Abstract
Gu and colleagues utilized a conditional knockout of Tfap2c to examine transcriptional effects of AP-2γ on mammary development. AP-2γ-deficient mice have decreased numbers of cell populations harboring mammary stem cells and have altered expression of genes required for mammary development, including Cebpb, Nfkbia, and Rspo1. They demonstrate that AP-2γ is implicated in maintenance of multipotent mammary stem cells.
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CITATION STYLE
Gu, V. W., Cho, E., Thompson, D. T., Cassady, V. C., Borcherding, N., Koch, K. E., … Weigel, R. J. (2021). AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells. Stem Cell Reports, 16(1), 106–119. https://doi.org/10.1016/j.stemcr.2020.12.002
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