PDZ domain proteins: Scaffolds for signaling complexes

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Abstract

InaD, a Drosophila photoreceptor scaffolding protein, assembles multiple signal-transducing proteins at the membrane via its five PDZ domains, enhancing speed and efficiency of vision. Extensive conservation of PDZ domains suggests that these motifs have a general role in organizing diverse signaling complexes.

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Ranganathan, R., & Ross, E. M. (1997, December 1). PDZ domain proteins: Scaffolds for signaling complexes. Current Biology. Cell Press. https://doi.org/10.1016/s0960-9822(06)00401-5

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