The role of vitamin D in the pathogenesis of genital endometriosis

Abstract

The influence of vitamin D on the women’s health is undeniable. Here we review the modern classification of vitamin D forms and receptors, the current understanding of genomic and non-genomic regulation pathways of vitamin D synthesis. It was found that a vitamin D deficiency related to the development of many diseases, negative impact on reproductive function and pregnancy outcomes. Nowadays, vitamin D is concerned as a prohormone that has multiple effects. Special attention is given to the role of vitamin D in the pathogenesis of genital endometriosis. It is known that vitamin D has anti-inflammatory, antiproliferative and immunomodulating effects, which allow it to be considered as a forward-looking target therapy in endometriosis. (For citation: Denisova AS, Yarmolinskaya MI. The role of vitamin D in the pathogenesis of genital endometriosis. Journal of Obstetrics and Women’s Diseases. 2017;66(6):81-88. doi: 10.17816/JOWD66681-88).