The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy

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Abstract

Millions of people have been affected ever since the emergence of the corona virus disease of 2019 (COVID-19) outbreak, leading to an urgent need for antiviral drug and vaccine development. Current experimentation on traditional two-dimensional culture (2D) fails to accurately mimic the in vivo microenvironment for the disease, while in vivo animal model testing does not faithfully replicate human COVID-19 infection. Human-based three-dimensional (3D) cell culture models such as spheroids, organoids, and organ-on-a-chip present a promising solution to these challenges. In this report, we review the recent 3D in vitro lung models used in COVID-19 infection and drug screening studies and highlight the most common types of natural and synthetic polymers used to generate 3D lung models.

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Ahmed, T. A., Eldaly, B., Eldosuky, S., Elkhenany, H., El-Derby, A. M., Elshazly, M. F., & El-Badri, N. (2023, December 1). The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy. Stem Cell Research and Therapy. BioMed Central Ltd. https://doi.org/10.1186/s13287-023-03341-4

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