Abstract
The key intermediate to squalamine, (5α, 7α, 24R)-7,24-dihydroxy-cholestan-3-one, was synthesized from the 3-O-acetyl-24R,25-dihydroxy derivative of desmosterol via 10 steps in 16% overall yield and squalamine was also prepared via two further steps in 7.4% total yield from the desmosterol derivative. © 2003 Pharmaceutical Society of Japan.
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Okumura, K., Nakamura, Y., Takeuchi, S., Kato, I., Fujimoto, Y., & Ikekawa, N. (2003). Formal synthesis of squalamine from desmosterol. Chemical and Pharmaceutical Bulletin, 51(10), 1177–1182. https://doi.org/10.1248/cpb.51.1177
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