Keratometric index obtained by fourier-domain optical coherence tomography

Abstract

Purpose: To determine the keratometric indices calculated based on parameters obtained by Fourier-domain optical coherence tomography (FD-OCT). Methods: The ratio of anterior corneal curvature to posterior corneal curvature (Ratio) and keratometric index (N) were calculated within central 3 mm zone with the RTVue FD-OCT (RTVue, Optovue, Inc.) in 186 untreated eyes, 60 post-LASIK/PRK eyes, and 39 keratoconus eyes. The total corneal powers were calculated using different keratometric indices: K cal based on the mean calculated keratometric index, K 1.3315 calculated by the keratometric index of 1.3315, and K 1.3375 calculated by the keratometric index of 1.3375. In addition, the total corneal powers based on Gaussian optics formula (K actual) were calculated. Results: The means for Ratio in untreated controls, post-LASIK/PRK group and keratoconus group were 1.176 ± 0.022 (95% confidence interval (CI), 1.172-1.179), 1.314 ± 0.042 (95%CI, 1.303-1.325) and 1.229 ± 0.118 (95%CI, 1.191-1.267), respectively. And the mean calculated keratometric index in untreated controls, post-LASIK/PRK group and keratoconus group were 1.3299 ± 0.00085 (95%CI, 1.3272-1.3308), 1.3242 ± 0.00171 (95%CI, 1.3238-1.3246) and 1.3277 ± 0.0046 (95%CI, 1.3263-1.3292), respectively. All the parameters were normally distributed. The differences between K cal and K actual, K 1.3315 and K actual, and K 1.3375 and K actual were 0.00 ± 0.11 D, 0.21 ± 0.11 D and 0.99 ± 0.12 D, respectively, in untreated controls; -0.01 ± 0.20 D, 0.85 ± 0.18 D and 1.56 ± 0.16 D, respectively, in post-LASIK/PRK group; and 0.03 ± 0.67 D, 0.56 ± 0.70 D and 1.40 ± 0.76 D, respectively, in keratoconus group. Conclusion: The calculated keratometric index is negatively related to the ratio of anterior corneal curvature to posterior corneal curvature in untreated, post-LASIK/PRK, and keratoconus eyes, respectively. Using the calculated keratometric index may improve the prediction accuracies of total corneal powers in untreated controls, but not in post-LASIK/PRK and keratoconus eyes.