Abstract
We examined the vascular structure and endothelium-dependent relaxation in two genetic models of hypercholesterolemia: apolipoprotein E (apoE)- knockout mice and combined apoE/LDL receptor-double-knockout mice. Intimal area was increased markedly in proximal segments of thoracic aortas from apoE/LDL receptor-knockout mice [0.13±0.03 (mean±SE) mm2] compared with normal (C57BL/6J) mice (0.002±0.002 mm2, P
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Bonthu, S., Heistad, D. D., Chappell, D. A., Lamping, K. G., & Faraci, F. M. (1997). Atherosclerosis, vascular remodeling, and impairment of endothelium- dependent relaxation in genetically altered hyperlipidemic mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 17(11), 2333–2340. https://doi.org/10.1161/01.ATV.17.11.2333
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