Objective: To carefully examine the features of controlled ovarian stimulation performed with recombinant FSH-α or hMG. Design: Controlled, prospective, randomized comparison of fixed gonadotropin regimens. Setting: Academic research institution. Patient(s): Fifty infertile patients who were candidates for IUI. Intervention(s): Patients were randomized to receive a fixed regimen of recombinant FSH-α (150 IU/day, 25 patients) or hMG (150 IU/day, 25 patients), after GnRH-agonist suppression (long regimen). Main outcome measure(s): Daily measurements of serum LH, immunoreactive FSH, hCG, E2, P, and T. Transvaginal pelvic ultrasound every 2 days. Pregnancy and abortion rates. Cost of medications. Result(s): Two recombinant FSH-α-treated patients did not respond. Despite matched daily FSH dose, duration of treatment (hMG 10.8 ± 0.4 vs. recombinant FSH-α 12.4 ± 0.5 days), gonadotropin dose (21.7 ± 0.8 vs. 25.3 ± 1.3 ampoules), gonadotropin cost (288 ± 10 vs. 1,299 ± 66 €/cycle), serum P levels, and small preovulatory follicle number were significantly lower, and LH, hCG, immunoreactive FSH levels, and larger follicles on day 8 were significantly higher in hMG-treated patients. The pregnancy, abortion, and twin pregnancy rates did not differ. Conclusion(s): The hMG administration was associated with:  increased serum LH activity and immunoreactive FSH levels during treatment;  reduced signs of premature luteinization;  differential modulation of folliculogenesis;  lower treatment duration, gonadotropin dose, and cost; and  clinical outcome comparable to recombinant FSH-α. © 2003 by American Society for Reproductive Medicine.
Filicori, M., Cognigni, G. E., Pocognoli, P., Tabarelli, C., Ferlini, F., Perri, T., & Parmegiani, L. (2003). Comparison of controlled ovarian stimulation with human menopausal gonadotropin or recombinant follicle-stimulating hormone. Fertility and Sterility, 80(2), 390–397. https://doi.org/10.1016/S0015-0282(03)00594-6