An efficient synthesis of spiro[indoline-3,9-xanthene]trione derivatives catalyzed by magnesium perchlorate

Abstract

A simple and efficient method for the synthesis of spiro[indoline-3,9-xanthene]trione derivatives by means of condensation between isatins and 1,3-cyclohexanedione in the presence of a catalytic amount of magnesium perchlorate at 80◦C in 50% aqueous ethanol medium has been described. Notably, the present method offers desirable advantages of good yields, simplicity of workup procedure, easy purification, and reduced reaction times.