Synthesis, characterization and biological evaluation of some novel Benzimidazole derivatives

Abstract

The benzimidazole nucleus has a significant importance in medicinal chemistry and many benzimidazole-containing compounds exhibit important biological activities. In the present study, synthesis, spectral studies and biological evaluation of nine novel benzimidazole derivatives were investigated. The structures of the synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, Mass spectroscopy and CHN elemental analyzer and the target new synthesized compounds (1c-9c) screened for antibacterial activity against various strains of Escherichia coli and Staphylococcus aureus and antifungal activity against Candida albicans. © 2014 Bulgarian Academy of Sciences, Union of Chemists in Bulgaria.