Abstract
A promising modified sugar molecule was identified which was active against multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, suggesting involvement of a new target. The compound was demonstrated to be bactericidal, inhibited the growth of M. tuberculosis in mice, and targeted alpha-mannosidase as a competitive inhibitor with a Ki value of 353.9 μM. © 2014, American Society for Microbiology.
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APA
Kashyap, V., Sharma, S., Singh, V., Sharma, S. K., Saquib, M., Srivastava, R., & Shaw, A. K. (2014). Deoxysugars as antituberculars and alpha-mannosidase inhibitors. Antimicrobial Agents and Chemotherapy, 58(6), 3530–3532. https://doi.org/10.1128/AAC.02715-13
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