Impact of bovine and human serum albumin on Curcumin in vitro activity against Staphylococcus aureus

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Abstract

This study evaluated the impact of pH (7.4 and 6.5), bovine serum albumin (BSA), and human serum albumin (HSA) on Curcumin activity against 2 reference, 1 clinical, and 10 environmental strains of Staphylococcus aureus (S. aureus). Minimal inhibitory concentrations (MICs) of Curcumin against S. aureus were statistically indifferent (p>0.05) at pH7.4 and pH6.5. Activity of Curcumin against S. aureus was reduced by two folds in the presence of 1.25-5% BSA/HSA.

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Teow, S. Y., & Ali, S. A. (2017). Impact of bovine and human serum albumin on Curcumin in vitro activity against Staphylococcus aureus. Pakistan Journal of Pharmaceutical Sciences, 30(3), 891–895. https://doi.org/10.36721/pjps/30/3/03.05.2017/3307/891-895

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