Apoptosis-Sensitizing Tumor Nanomedicine by Regulating Pyroptosis-Associated Inflammatory Cell Death

Abstract

The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation of cunning cancer cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory-regulated cell death (RCD), especially pyroptosis-related cell death, demonstrates huge potential for apoptosis sensitization due to its unique biochemical characteristics. The aim of this research is to present a thorough synopsis of the current knowledge on pyroptosis-associated inflammatory cell death, including pyroptosis, cuproptosis, and PANoptosis, and the synergistic function in cancer nano therapy. Paradigm studies of pyroptosis-related cell death-mediated apoptosis-sensitizing tumor nanotherapeutics are introduced in detail, and the coordination mechanisms based on nanomaterials are also discussed. In addition, multi-angle analysis of the future prospects of pyroptosis-sensitized tumor nanomedicine based on various nanomaterials is also emphasized to further expand the application scope of inflammatory RCD. It is believed that emerging auxiliary apoptosis-sensitizing treatments based on inflammatory RCD will greatly promote the progress of cancer nanomedicine.