Wnt/β-catenin signaling plays critical roles in embryonic development and tissue homeostasis in adults by controlling the expression of target genes. We found that expression of ptpro, which encodes a protein tyrosine phosphatase receptor type O (PTPRO), was induced by Wnt/β-catenin signaling in a T cell factor/lymphoid enhancer factor dependent manner. Biochemical assays found that PTPRO interacted with Wnt via its extracellular domain. In addition, ectopic expression of this extracellular domain inhibited Wnt-mediated reporter activity. These results suggest that ptpro is a target gene of Wnt/β-catenin signaling and that PTPRO may function as a novel receptor for Wnt. Structured summary: MINT- 7992076: Ptpro (uniprotkb:. Q7TSY7) physically interacts (MI:. 0915) with Wnt3a (uniprotkb:. P27467) by anti tag coimmunoprecipitation (MI:. 0007). MINT- 7992094: Ptpro (uniprotkb:. Q7TSY7) physically interacts (MI:. 0915) with Wnt-3a (uniprotkb:. P27467) by cross-linking study (MI:. 0030). © 2010 Federation of European Biochemical Societies.
Kim, M., Kim, H., & Jho, E. hoon. (2010). Identification of ptpro as a novel target gene of Wnt signaling and its potential role as a receptor for Wnt. FEBS Letters, 584(18), 3923–3928. https://doi.org/10.1016/j.febslet.2010.08.034