Antinociceptive and anti-inflammatory effects of ethanolic extract of Salvia syriaca L. in Mice

Abstract

The aim of this study was to evaluate the antinociceptive and anti-inflammatory effect of Salvia syriaca L. aerial parts ethanolic extract in male NMRI mice. Antinociceptive activity was done using by formalin, hot plate and writhing tests. The effect of ethanolic extract on acute inflammation was studied by xylene edema test in mice. The Salvia syriaca L. ethanolic extract (1, 10, 50 and 100 mg kg-1 body wt.) was injected intraperitoneally. The control group administrated with saline. Present results showed that the ethanolic extract decreased only second phase of formalin-induced pain. In hot plate test, the ethanolic extract did not raise pain threshold during 60 mins. The ethanolic extract exhibited antinociceptive activity against writhing-induced by acetic acid. In xylene ear edema test, Salvia syriaca L. ethanolic extract showed significant activity in the mice. The present data indicated that this plant has antinociceptive and anti-inflammatory effect on the mice but more works are required to be done in order to elucidate the mechanism (s) involved in antinociceptive and anti-inflammatory effects of the Salvia syriaca L. extract. © 2011 Asian Network for Scientific Information.