Influence of (ATP)-binding cassette transporter subfamily B member 1 (ABCB1) gene polymorphism on the efficacy of remifentanil

Abstract

Background: The aim of this study was to investigate the influence of adenosine triphosphate (ATP)-binding cassette transporter subfamily B member 1 (ABCB1) gene polymorphism on the efficacy of Remifentanil. Material/Methods: A total of 276 patients undergoing elective surgeries were included to collect general clinical information and detect the polymorphism of ABCB1 rs1045642 using the TaqMan-MGB probe, and they were divided into 3 groups-a genotype AA group, a genotype AG group, and a genotype GG group-based on different genotypes of ABCB1 rs1045642. Results: The comparisons showed that there were no differences in sex, age, body mass index (BMI), smoking, drinking status, or ASA class among the 3 groups (P>0.05). The genotype GG group had higher consumption of Remifentanil than the genotype AA group (P<0.05), but the genotype AG group was not different from the genotype AA and GG groups (P>0.05). Comparison of the surgery duration revealed no difference among the 3 groups (P>0.05). The analepsia time, autonomous respiratory recovery time, and orientation recovery time in the genotype GG group were longer than in the genotype AA group (P<0.05), but the genotype AG group was not different from the genotype AA and GG groups (P>0.05). There were no differences in adverse reactions among the 3 groups (P>0.05). Conclusions: ABCB1 gene polymorphism can affect the clinical efficacy of Remifentanil.