Second lymphoid neoplasms are an uncommon but recognized feature of non-Hodgkin's lymphomas, putatively arising secondary to common genetic or environmental risk factors. Previous limited evaluations of clonal relatedness between successive mature B-cell malignancies have yielded mixed results. We describe the case of a man with intravascular large B-cell lymphoma involving the central nervous system who went into clinical remission following immunochemotherapy and brain radiation, only to relapse 2 years later with a plasmacytoma of bone causing cauda equina syndrome. The plasmacytoma stained strongly for the cell cycle regulator cyclin D1 on immunohistochemistry, while the original intravascular large cell lymphoma was negative, a disparity providing no support for clonal identity between the 2 neoplasms. Continued efforts atcataloging and evaluating unique associations of B-cell malignancies are critical to improving understanding of overarching disease biology in B-cell malignancies. © 2014 Joycelyn Lee et al.
Lee, J., Tan, S. Y., Tan, L. H. C., Lee, H. Y., Chuah, K. L., Tang, T., … Farid, M. (2014). One patient, two uncommon B-cell neoplasms: Solitary plasmacytoma following complete remission from intravascular large B-cell lymphoma involving central nervous system. Case Reports in Medicine, 2014. https://doi.org/10.1155/2014/620423