Stabilizers influence drug-polymer interactions and physicochemical properties of disulfiram-loaded poly-lactide-co-glycolide nanoparticles

Abstract

Aim: Stabilizers are known to be an integral component of polymeric nanostructures. Ideally, they manipulate physicochemical properties of nanoparticles. Based on this hypothesis, we demonstrated that disulfiram (drug) and Poly-lactide-co-glycolide (polymer) interactions and physicochemical properties of their nanoparticles formulations are significantly influenced by the choice of stabilizers. Methodology: Electron microscopy, differential scanning calorimetry, x-ray diffraction, Raman spectrum analysis, isothermal titration calorimetry and in silico docking studies were performed. Results & discussion: Polysorbate 80 imparted highest crystallinity while Triton-X 100 imparted highest rigidity, possibly influencing drug bioavailability, blood-retention time, cellular uptake and sustained drug release. All the molecular interactions were hydrophobic in nature and entropy driven. Therefore, polymeric nanoparticles may be critically manipulated to streamline the passive targeting of drug-loaded nanoparticles. Lay abstract Polymeric nanoparticles are futuristic drug-delivering platforms that have many potential advantages above conventional drug-delivery tools. They are mainly composed of a polymer, stabilizer and the therapeutic ingredient. A number of researches are on-going to improvise various characteristics of polymeric nanoparticles, in order to enhance its efficacy. The current study is one such domain where we emphasize on identifying potential stabilizing factors that are involved in nanoparticles formation and their drug entrapment and release properties.