Differential Pax6 promoter activity and transcript expression during forebrain development

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Abstract

Three different Pax6 promoters - P0, P1, and Pα - show differential activity in the developing eye and spinal cord. To examine promoter usage during forebrain development, we performed in situ hybridization and reverse transcription-polymerase chain reaction to detect transcripts initiated from each promoter. Promoter-specific transcripts are expressed within subdomains of total Pax6 expression, but differ from one another in their spatial localization and expression over time. Additionally, we identified a novel P0-initiated transcript and detected a developmentally regulated antisense transcript. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

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Anderson, T. R., Hedlund, E., & Carpenter, E. M. (2002). Differential Pax6 promoter activity and transcript expression during forebrain development. Mechanisms of Development, 114(1–2), 171–175. https://doi.org/10.1016/S0925-4773(02)00051-5

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