Disparities in Acceptance of Deceased Donor Kidneys between the United States and France and Estimated Effects of Increased US Acceptance

Abstract

Importance: Approximately 3500 donated kidneys are discarded in the United States each year, drawing concern from Medicare and advocacy groups. Objective: To estimate the effects of more aggressive allograft acceptance practices on the donor pool and allograft survival for the population of US wait-listed kidney transplant candidates. Design, Setting, and Participants: A nationwide study using validated registries from the United States and France comprising comprehensive cohorts of deceased donors with organs offered to kidney transplant centers between January 1, 2004, and December 31, 2014. Data were analyzed between September 1, 2018, and April 5, 2019. Main Outcomes and Measures: The primary outcome was kidney allograft discard. The secondary outcome was allograft failure after transplantation. We used logistic regression to model organ acceptance and discard practices in both countries. We then quantified using computer simulation models the number of kidneys discarded in the United States that a more aggressive system would have instead used for transplantation. Finally, based on actual survival data, we quantified the additional years of allograft life that a redesigned US system would have saved. Findings: In the United States, 156089 kidneys were recovered from deceased donors between 2004 and 2014, of which 128102 were transplanted, and 27987 (17.9%) were discarded. In France, among the 29984 kidneys recovered between 2004 and 2014, 27252 were transplanted, and 2732 (9.1%, P