Lipoic acid is almost universally required for aerobic metabolism. However, the mechanism for its synthesis and incorporation into proteins has remained elusive. A groundbreaking study published in the December issue of Chemistry & Biology  uncovers critical features of the lipoic acid biosynthetic pathway.
Booker, S. J. (2004). Unraveling the Pathway of Lipoic Acid Biosynthesis. Chemistry and Biology. Elsevier Ltd. https://doi.org/10.1016/j.chembiol.2004.01.002