Multiple myeloma with plasmacytoma of the clivus bone presenting with multiple cranial nerve III , IV , and VI palsy: A diagnostic dilemma

Abstract

Central nervous system (CNS) manifestation with cranial nerve palsy in multiple myeloma (MM) is a rare manifestation. Plasmacytoma originates from the bones of the skull base in 3% patients with MM but rarely develops from the soft tissues of the nasal cavity and paranasal sinuses. Here, we present a case of 68‐year‐old male patient with multiple myeloma, clivus bone plasmacytoma, and cavernous sinus syndrome.Clivus bone plasmacytoma with MM is a rare condition. Our patient presented with the pain in frontal and periorbital region, blurry vision and backache. Any patient presenting with these symptoms along with lytic bone lesions on imaging should be evaluated for MM.