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Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors

Neuron (2019) 102(5) 976-992.e5
DOI: 10.1016/j.neuron.2019.03.046
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Abstract

Combining electrophysiology, atomic force microscopy, and X-ray crystallography, Dawe et al. reveal that nanoscale mobility of the apo state and TARP stoichiometry coordinate the responsiveness of alternatively spliced AMPA receptors to neurotransmitter, allosteric anions, and TARP auxiliary proteins.

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Dawe, G. B., Kadir, M. F., Venskutonytė, R., Perozzo, A. M., Yan, Y., Alexander, R. P. D., … Bowie, D. (2019). Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors. Neuron, 102(5), 976-992.e5. https://doi.org/10.1016/j.neuron.2019.03.046

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