7-Chloro-4,6–dimethoxy-1 (3H)-isobenzofurane and Basidalin: Antibiotic Secondary Metabolites from Leucoagaricus carneifolia Gillet (Basidiomycetes)

Abstract

Two, antibiotic metabolites were isolated from cultures of Leucoagaricus carneifolia. Their structures were elucidated by spectroscopic methods. The first compound, 7–chloro-4,6–di-methoxy-l(3H)-isobenzofurane (1) had to our knowledge not been described from natural sources whereas the second, basidalin (2), is a known metabolite of, L. naucina (H. Iinuma et al., 1983). 1 exhibits antibiotic activities with minimal inhibitory concentrations of 20 µg/ml against Botrytis cinerea, the most sensitive microorganism. © 1994, Walter de Gruyter. All rights reserved.