Time-dependent changes of atherosclerotic LDL complexes after smoking cessation

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Abstract

Aim: The α1-antitrypsin - low-density lipoprotein complex (AT-LDL and serum amyloid A-LDL complex (SAA-LDL are oxidatively modified LDL complexes that promote atherosclerosis. The serum levels of AT-LDL and SAA-LDL are suggested to be increased by obesity and smoking. We have previously demonstrated that larger weight gain after smoking cessation (SC perturbs a decrease in the serum level of AT-LDL at 3 months after SC. However, changes of these atherosclerotic makers >3 months after SC are unknown. This study investigated post-SC time-dependent changes in two atherogenic lipoproteins, AT-LDL and SAA-LDL, and in the extent of abdominal obesity. Methods: In 50 outpatients who had continued SC for 1 year, we measured serum AT-LDL and SAA-LDL levels by the enzyme-linked immunosorbent assay before SC, and at 3 months and 1 year after SC. Results: Both body mass index and waist circumstance significantly increased from pre-SC to 3 months after SC and from 3 months after SC to 1 year after SC. Although the serum levels of ATLDL and SAA-LDL were unchanged from pre-SC to 3 months after SC, these levels decreased significantly from 3 months after SC to 1 year after SC. Conclusions: The extent of abdominal obesity and levels of two atherogenic lipoproteins time-dependently change after SC. Although abdominal obesity progressively worsened after SC, the beneficial effect of non-smoking overcomes the potential vascular risks by cessation-associated obesity at 1 year after SC.

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APA

Komiyama, M., Shimada, S., Wada, H., Yamakage, H., Satoh-Asahara, N., Shimatsu, A., … Hasegawa, K. (2016). Time-dependent changes of atherosclerotic LDL complexes after smoking cessation. Journal of Atherosclerosis and Thrombosis, 23(11), 1270–1275. https://doi.org/10.5551/jat.34280

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