The RNA polymerase 'bridge helix' is a metastable α-helix that spans the leading edge of the enzyme active-site cleft. A new study published in BMC Biology reveals surprising tolerance to helix-disrupting changes in a region previously thought crucial for translocation, and suggests roles for two hinge-like segments of the bridge helix in coordinating modules that move during the nucleotide-addition cycle. © 2010 Hein and Landick; licensee BioMed Central Ltd.
Hein, P. P., & Landick, R. (2010, November 29). The bridge helix coordinates movements of modules in RNA polymerase. BMC Biology. https://doi.org/10.1186/1741-7007-8-141