3-Aminobenzamide inhibition of protein kinase C at a cellular level

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Abstract

3-Aminobenzamide, a known inhibitor of poly-(ADP-ribose)-polymerase has been found in the cell line U-937 to inhibit protein kinase C at the same concentration as poly-(ADP-ribose)-polymerase. 3-Aminobenzamide was not able, however, to inhibit the isolated enzyme. An indirect mechanism of protein kinase C inhibition is proposed.

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Ricciarelli, R., Palomba, L., Cantoni, O., & Azzi, A. (1998). 3-Aminobenzamide inhibition of protein kinase C at a cellular level. FEBS Letters, 431(3), 465–467. https://doi.org/10.1016/S0014-5793(98)00811-4

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