Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.
Barzilai, N., Crandall, J. P., Kritchevsky, S. B., & Espeland, M. A. (2016, June 14). Metformin as a Tool to Target Aging. Cell Metabolism. Cell Press. https://doi.org/10.1016/j.cmet.2016.05.011