The authors focused on the amplification of data on the mutagenicity of selected trichothecene mycotoxins (T-2 toxin, vomitoxin) and their combination with aflatoxin B1, which is known to be a strong mutagen. Mutagenic activity was investigated using the Ames test in a prokaryote model at low doses (close to 0.1 LD50). Whereas the individual trichothecene mycotoxins (T-2 toxin, vomitoxin) did not show any mutagenic activity in the test systems mentioned, in combination with AFB1, or as a combination of all three mycotoxins, they showed a mutagenic effect significantly greater than AFB1 alone in the Ames test (in strain TA98 at all concns.) as well as in the micronucleus test (combination of T-2 toxin with AFB1). [on SciFinder (R)]
CITATION STYLE
Šmerák, P., Bárta, I., Polívková, Z., Bártová, J., & Sedmíková, M. (2001). Mutagenic effects of selected trichothecene mycotoxins and their combinations with aflatoxin B 1. Czech Journal of Food Sciences, 19(3), 90–96. https://doi.org/10.17221/6583-cjfs
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