Effects of moxibustion pretreating on SOD and MDA in the rat of global brain ischemia

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Abstract

Objective: To probe into the mechanism of moxibustion preconditioning in preventive brain-protecting effect. Methods: The global brain ischemia rat model was developed by blocking 4 arteries. Seventy-eight Wistar male rats were randomly divided into 5 groups: a normal control group, a sham-operation group, a brain ischemia group, a brain ischemia preconditioning group, a moxibustion pretreating group. The brains in the 5 groups were taken at 24 h, 48 h, and 72 h after operation respectively. Superoxide dismulase (SOD) activity was determined with xanthine oxidase method and malondialdehyde (MDA) content with thiobarbituric acid method. Results: After the operation, in the moxibustion preconditioning group, SOD activity significantly increased, especially 24 h after moxibustion preconditioning; and MDA content decreased, with a very significant difference as compared with that of the cerebral ischemia group (P<0.01). Conclusion: Moxibustion preconditioning protects the ischemic and anoxic brain tissue by increasing the activity of endogenous antioxidase.

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Hua, J. S., Li, L. P., & Zhu, X. M. (2008). Effects of moxibustion pretreating on SOD and MDA in the rat of global brain ischemia. Journal of Traditional Chinese Medicine, 28(4), 289–292. https://doi.org/10.1016/s0254-6272(09)60014-5

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