Determination of cytokine status indicators and angiogenesis factors in patients with external genital endometriosis and vitamin d deficiency

Abstract

The study was performed to find an association between some cytokine status indicators, level of vascular endothelial growth factors, and vitamin D in women with infertility and external genital endometriosis (EGE) in order to increase the effectiveness of treatment of this pathology. The low vitamin D status in the dynamics was determined in 240 patients aged 25 to 35 years with EGE planning pregnancy by determining the level of 25 (OH) D in the blood serum using the chemiluminescent method. Interleukin status (IL-1β, IL-6, IL-4), TNF-α, VEGF-R1 in blood serum were determined using enzyme-multiple immunoassay. The results of the studies revealed an increased level of IL-6, IL-1β, and TNF-α in groups with low vitamin D content. In normal vitamin D significantly lower levels of vascular endothelial growth factor (VEGF-R1) in the blood serum were registered. Pregnancy rates were higher in groups with normal 25 (OH) D levels in the blood serum. The mean serum VEGF-R1 level in pregnant women who became pregnant on their own was 1.3-1.5 times lower.