Síntese e caracterização de complexos de platina(IV) com derivados N-benzilados da 1,3-propanodiamina

Abstract

Recebido em 18/6/09; aceito em 2/3/10; publicado na web em 10/6/10 SYNTHESIS AND CHARACTERIZATION OF PLATINUM(IV) COMPLEXES DERIVED FROM N-BENZYL-PROPANEDIAMINE. The present work describes the synthesis of a series of platinum(IV) complexes with N-benzyl 1,3-propanediamine derivatives. Since substitution of the axial ligands in the platinum(IV) complexes may alter their pharmacological properties, we have prepared complexes with different groups, such as hydroxide, chloride and acetate using a sequence of substitution reactions. The resulting complexes were fully characterized by IR, 1 H, 13 C and 195 Pt NMR spectroscopies, and elemental analysis.