Comparison of Amplicor and Genexpert MTB/RIF Tests for diagnosis of Tuberculous meningitis

Abstract

There are no data about the comparative accuracy of commercially available nucleic acid amplification tests (GeneXpert MTB/ RIF and Roche Amplicor) for the diagnosis of tuberculous meningitis (TBM). A total of 148 patients with suspected TBM were evaluated, and cultures served as the reference standard. The sensitivities and specificities (95% confidence interval [CI]) for the Amplicor and Xpert MTB/RIF tests were similar: 46 (31- 60) versus 50 (33- 67) and 99 (93-100) and 94 (84 -99), respectively. Copyright