It has long been appreciated that inflammation and infection reduce drug metabolism and that exposure to drug metabolism-inducing xenobiotics can impair immune function. A new study reveals the mutual repression between the xenobiotic nuclear receptor PXR/SXR and NF-κB signaling pathways, providing a molecular mechanism linking xenobiotic metabolism and inflammation (Zhou et al., 2006). © 2006 Elsevier Inc. All rights reserved.
Xie, W., & Tian, Y. (2006, September). Xenobiotic receptor meets NF-κB, a collision in the small bowel. Cell Metabolism. https://doi.org/10.1016/j.cmet.2006.08.004