Microneedle‐Integrated Device for Transdermal Sampling and Analyses of Targeted Biomarkers

Abstract

Microneedle Patches In article number 2200087, Roger J. Narayan and co-workers report the design of a disposable device for interstitial fluid (ISF) extraction, as well as glucose, lactate, and potassium ion (K+) monitoring. The microscale device contains a 3D-printed cap-like structure in a four-by-four microneedle (MN) array. Each MN is fabricated via a Digital Light Processing 3D-printing process from a yellow transparent resin containing a mixture of two methacrylate oligomers, diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide photoinitiator, and a lauryl methacrylate reactive diluent. Each MN is conical in shape with a shank height of 900 μm; the diameter of the hollow portion of the MN is 320 μm.