Histone protein synthesis is activated as cells enter S phase to allow packaging of the newly replicated DNA into chromatin. In this issue of Developmental Cell, Takayama and coworkers elucidate a mechanism for silencing histone expression at the end of S phase in S. pombe. Failure to shut off histone expression disrupts centromeric chromatin structure.
Marzluff, W. F. (2010, March 16). Terminating Histone Synthesis to Preserve Centromere Integrity. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2010.03.004