Myocardial ischemia: lack of coronary blood flow, myocardial oxygen supply-demand imbalance, or what? Am J Physiol Heart Circ Physiol 316: H1439 –H1446, 2019. First published April 19, 2019; doi:10.1152/ajpheart.00139.2019.—This opinionated article reviews current concepts of myocardial ischemia. Specifically, the historical background is briefly presented. Then, the prevailing paradigm of myocardial oxygen-supply-demand imbalance is criticized since demand is a virtual parameter that cannot be measured and data on measurements of myocardial blood flow and contractile function rather support matching between flow and function. Finally, a concept of myocardial ischemia that focusses on the reduction of coronary blood flow to below 8 –10 μl/g per beat with consequences for myocardial electrical, metabolic, contractile and morphological features is advocated.
CITATION STYLE
Heusch, G. (2019). Myocardial ischemia: Lack of coronary blood flow, myocardial oxygen supply-demand imbalance, or what? American Journal of Physiology - Heart and Circulatory Physiology, 316(6), H1439–H1446. https://doi.org/10.1152/ajpheart.00139.2019
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