The contribution of disease and drug related factors to non-compliance with directly observed treatment short-course among tuberculosis patients

Abstract

The non-compliance to anti-tuberculosis therapy has been cited as a major barrier to the control of TB. There are different factors that are involved in non-compliance of TB. The Cross sectional prospective study was interviewed by using set of questionnaire. The enrolled patients of TB at DOTS centre of LRS Institute of Tuberculosis and Respiratory disease New Delhi, India. Patients who discontinue and interrupted treatment for more than 2 months were categorized as noncompliance cases. T-test was used for comparing the means of control and case groups. The default rate of Delhi LRS-RNTCP defined area was 3.53%. The 60% of non-compliance occurred in category II patients. Maximum patients were 3+ initial bacillary load (42.5%). 27.5% had positive influence to the non-compliance in response to problem created by TB. The patients who suffered adverse drug reaction and toxicity of drug contribute to highest rate and it was 40% and 22.5% had no any role non-compliance of tuberculosis patients. Drug related factors were major factors involved in non-compliance of tuberculosis treatment. Thus we recommend that the ADR monitoring and least ADR active drug should be used.