Synthesis, spectral characterization and anticancer studies of some metal(II) complexes derived from imidazole-2-carboxaldehyde with 2-amino-3-carboxyethyl-4,5-dimethylthiophene

Abstract

Imidazole-2-carboxaldehyde was condensed with 2-amino-3-carboxyethyl-4,5-dimethyl thiophene in 1:1 molar ratio yielded Schiff base ligand. Cobalt(II), nickel(II), copper(II) and zinc(II) complexes of the ligand were synthesized and characterized structurally using elemental analysis, molar conductance, magnetic moment, infrared and electronic spectra. The ligand structure was confirmed by proton nuclear magnetic resonance spectrum. The geometry exhibited by the complexes was proposed using magnetic and electronic spectral data. Thermal analysis was carried out to ascertain the thermal stability of the compounds. The fluorescence spectral analysis were investigated at different solvents for the ligand and copper(II) complex. Using powder X-ray diffraction measurements, the grain size was determined. The scanning electron microscope images indicate the surface morphology of the complexes. The antibacterial and antifungal activities were screened by disk diffusion method designed by Kirby-Bauer. In vitro anticancer studies were carried out, by MTT assay for human cervical carcinoma cell line.