Abstract
Treatment of hepatitis C virus with potent, interferon-free, direct-acting antiviral regimens with no activity against hepatitis B virus (HBV) may increase the risk for HBV reactivation in coinfected patients. We present 2 cases of HBV reactivation during treatment with an all-oral regimen of simeprevir and sofosbuvir and discuss strategies to prevent HBV flare.
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Collins, J. M., Raphael, K. L., Terry, C., Cartwright, E. J., Pillai, A., Anania, F. A., & Farley, M. M. (2015). Hepatitis B Virus Reactivation during Successful Treatment of Hepatitis C Virus with Sofosbuvir and Simeprevir. Clinical Infectious Diseases, 61(8), 1304–1306. https://doi.org/10.1093/cid/civ474
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