A benign and efficient synthesis of chiral macrocyclic 'aza-crown' ethers of varying ring size is reported. The synthesis involves a Schiff base condensation of ether linked dialdehydes of varying chain length and (1R,2R)-(-)-1,2-diaminocyclohexane under mild conditions to yield the macrocycles, which are subsequently reduced to yield the diamino analogues.
CITATION STYLE
Correa, W. H., & Scott, J. L. (2004). Synthesis and characterisation of macrocyclic diamino chiral crown ethers. In Molecules (Vol. 9, pp. 513–519). Molecular Diversity Preservation International. https://doi.org/10.3390/90600513
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