This artice is free to access.
This is the protocol for a review and there is no abstract. The objectives are as follows: To evaluate the effectiveness of chlorhexidine-containing oral products (toothpastes, mouthrinses, varnishes, gels, gums and sprays) in adults on reducing dental caries rates as compared with topical fluoride treatments, placebo or no treatment. To assess if there are optimum parameters of administration of chlorhexidine-containing oral products (e.g. form, concentration, frequency). To examine whether the effect of chlorhexidine-containing oral products is influenced by the level of caries in the population. To describe reported adverse effects, their rate of occurrence and potential to interfere with treatment. It is recognised that studies included in the review of effectiveness may not provide a comprehensive summary of adverse effects. The following null hypotheses will be tested. There is no difference in caries rates between adults using chlorhexidine-containing products compared with topical fluoride treatments, placebo or no treatment. There is no difference in caries rates between adults using chlorhexidine-containing products according to different parameters of administration (form, concentration, frequency).
Bailey, D., Adams, G., Marinho, V. C. C., Tsao, C., Hyslop, A., & Morgan, M. (2015). Chlorhexidine interventions for the prevention of caries in adults. Cochrane Database of Systematic Reviews, 2015(4). https://doi.org/10.1002/14651858.CD007856.pub2