IACUC issues related to animal models of aging

Abstract

The articles in this issue provide an excellent introduction to and overview of the use of various animal species as models for the study of human aging. Because of the welfare issues associated with such studies, we identify potential concerns that require attention to ensure the appropriate use and humane treatment of the animals involved. We also discuss the importance of model selection and endpoints for use by investigators, institutional animal care and use committees (IACUCs), and others.