Fibrinogen levels and leukocytes in diabetic Wistar rats at 0 hour to 96 hour post-induced by streptozotocin

Abstract

Diabetes mellitus is a metabolic disease called the silent killer because the patient is usually known when it becomes severe. Research is needed to know what are changes during early diabetes as a marker of diabetes such as fibrinogen and leukocytes that quickly respond when there are any changes in the body. Total 20 Wistar rats were divided into two groups of treatments and controls. Treatments rats become diabetes induced by streptozotocin and control rats are not induced. Blood samples were taken at (0 th , 6 th , 12 th , 24 th , 36 th , 48 th , 60 th , 72 th , 84 th , and 96 th ) h for testing blood glucose, fibrinogen, leukocyte, and differential leukocyte. Then the data are processed using SPSS, correlate bivariate and compare mean-independent samples T-test. From the calculation, it is known that the treatment and control rats have the significance of blood sugar level 0.001; fibrinogen levels of 0.000; total leukocyte count 0.017; neutrophil of 0.161; monocyte of 0.008 and lymphocyte of 0.023. There is a very strong correlation between blood sugar levels with fibrinogen of 0.91 and a very weak correlation between blood sugar levels and leukocytes by 0.659. It was concluded that fibrinogen could be an excellent marker and leukocytes are poor markers for early diabetes.