The effect of mechanical loading on articular cartilage

Abstract

The effect of mechanical loading on articular cartilage is the topic chosen for the second editorial of this newly launched journal. The aim of this interesting editorial is to illustrate the cell signaling correlated to the mechanical loading, some aspects of the mechanobiology and the positive and negative effects of the mechanical loading on articular cartilage. The benefits of the mechanical loading on articular cartilage have been shown to have a short- and long-term effectiveness. In this article, the role of mechanical signaling in the maintenance of articular cartilage and how the alterations in normal signaling can lead to joint pathology have been discussed.