Primary renal angiosarcoma: A case report and literature review

Abstract

Kidney angiosarcomas usually metastasize from the skin, soft tissue, or visceral primary lesions, whereas primary renal angiosarcomas are rare. We report a case of primary renal angiosarcoma with morphological features similar to those of anastomosis hemangioma. Microscopically, there were multiple irregular anastomosing vascular spaces or channel-like labyrinthine structures, and the tumor cells were positive for CD31, CD34, FLI-1, PAX8, and vimentin; focally positive for factor VIII, CD10, and Ki-67 (approximately 5%); and uniformly-negative for CK, S-100, and Melan-A. The diagnosis of angiosarcoma depends on morphological and immunohistochemical examinations.